Approach to a methodology for the detection and characterization of cognitive deficit in neurocognitive disorders of possible post-COVID-19 etiology

Abstract

The psychiatric and neurocognitive symptoms caused by COVID-19 can also appear late and persist after infection and therefore be part of the Post-COVID-19 Syndrome. Difficulties in the ability to concentrate or pay attention, memory, emotional lability, language alterations, euphoria, irritability and fatigue are symptoms that may be related to post-traumatic stress experienced by these patients. However, cognitive deterioration is evident when a decrease in performance in the domains of executive function, memory and attention is identified. These neurocognitive sequelae are one of the most reported and in turn, they are identified as those with the greatest impact and influence on the quality of life of post-COVID-19 patients. Materials and methods: To obtain the primary data, it will be extracted directly from the patient through an in-depth interview and physical examination that will be carried out on them, corroborating with family members, depending on the case, the validity of the information related to the clinical manifestations of symptoms of neurocognitive deficit and the time of their appearance, as well as the application of neuropsychological and neurophysiological techniques that will allow a more in-depth evaluation of the cognitive domains. Results: Particularly the neurophysiological studies that will be recorded in the study, constitute non-invasive and completely harmless diagnostic procedures, incorporation into the study will be carried out through the principle of voluntariness and the patient may withdraw from the study at any time. The presentation of the results will not include in any case the identity of the subjects or patients studied. Discussion: Particularly the neurophysiological studies that will be recorded in the study, constitute non-invasive and completely harmless diagnostic procedures, incorporation into the study will be carried out through the principle of voluntariness and the patient may withdraw from the study at any time. The presentation of the results will not include in any case the identity of the subjects or patients studied. Conclusions: It is important to note that Neuropsychological Tests are very useful for neuropsychological evaluation within clinical practice. However, since Post-COVID-19 Syndrome is a new entity in the field of research, we cannot consider its results conclusive. Therefore, there is a need to combine support tools that can objectively indicate the diagnosis of neurocognitive disorder, as well as the degree of severity and whether or not the deterioration is reversible. In addition, to evaluate its evolution and the result of neurocognitive intervention strategies.